ABSTRACT
Objective: To reduce extubation failure rate by implementing protocol-driven ventilation andextubation strategies. Methods: Quality improvement project in a level II neonatal care unitfrom April 2017 to January 2018. Ventilation and extubation protocols implemented from 1August, 2017. 18 ventilated newborns in the pre-protocol period, 16 in Plan-do-check-act(PDCA) cycle I and 17 in PDCA cycle II.Primary outcome wasextubation failure within thefirst 72 h of extubation. Results: Extubation failure rate reduced from 41.7% (pre-protocolperiod) to 23.8% (PDCA 1 and 2, OR 0.44, 95% CI 0.12 to 1.59, P = 0.21). Median time to firstextubation attempt significantly decreased (71.5 h to 38 h, P=0.046). Conclusions: Aprotocolized approach through quality improvement initiative demonstrated a sustainedimprovement in successful extubation with a significant reduction in the median time to firstextubation attempt in ventilated newborns